Food-Derived Pharmacological Modulators of the Nrf2/ARE Pathway: Their Role in the Treatment of Diseases

Oxidative stress, which refers to unbalanced accumulation of reactive oxygen species (ROS) levels in cells, has been linked to acute and chronic diseases. Nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays a vital role in regulating cytoprotective genes...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-02, Vol.26 (4), p.1016
Main Authors: Zhao, Feijie, Ci, Xinxin, Man, Xiaxia, Li, Jiajia, Wei, Zhentong, Zhang, Songling
Format: Article
Language:English
Subjects:
Animals
Antioxidant Response Elements - genetics
Antioxidants
Bioactive compounds
Chronic illnesses
Chronic obstructive pulmonary disease
Disease
Diseases
Food
Health services
Humans
Inflammation
Kidneys
Kinases
Medical treatment
Molecular modelling
Natural products
NF-E2-Related Factor 2 - metabolism
Nrf2
Oxidative stress
Pharmacology
Phytochemicals - pharmacology
Reactive oxygen species
Regulators
Review
Rodents
Signal Transduction
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Summary:Oxidative stress, which refers to unbalanced accumulation of reactive oxygen species (ROS) levels in cells, has been linked to acute and chronic diseases. Nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays a vital role in regulating cytoprotective genes and enzymes in response to oxidative stress. Therefore, pharmacological regulation of Nrf2/ARE pathway is an effective method to treat several diseases that are mainly characterized by oxidative stress and inflammation. Natural products that counteract oxidative stress by modulating Nrf2 have contributed significantly to disease treatment. In this review, we focus on bioactive compounds derived from food that are Nrf2/ARE pathway regulators and describe the molecular mechanisms for regulating Nrf2 to exert favorable effects in experimental models of diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26041016