Multicenter Study of Carbapenemase-Producing Enterobacterales in Havana, Cuba, 2016-2021

Surveillance of carbapenem resistance is particularly important for mainly in countries with limited healthcare resources. We conducted a cross-sectional study to detect carbapenem-resistant at 10 sentinel hospitals in Havana, Cuba for a six year-period (2016-2021) by the National Reference Laborato...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-04, Vol.11 (4), p.514
Main Authors: Yu, Haiyang, González Molina, María Karla, Carmona Cartaya, Yenisel, Hart Casares, Marcia, Aung, Meiji Soe, Kobayashi, Nobumichi, Quiñones Pérez, Dianelys
Format: Article
Language:English
Subjects:
Antibiotics
Carbapenemase
Communication
Coronaviruses
COVID-19
CRE bacteria
Cuba
Disease transmission
Drug resistance
E coli
Enterobacter cloacae
Enterobacter spp
Enterobacterales
Enzymes
Epidemiology
Genes
Health care
Hospitals
Infections
Intensive care units
Klebsiella
Klebsiella pneumoniae
Laboratories
Metallo-β-lactamase
Metallography
Microorganisms
NDM
Pandemics
Pathogens
Public health
Urinary tract
Urology
β Lactamase
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Summary:Surveillance of carbapenem resistance is particularly important for mainly in countries with limited healthcare resources. We conducted a cross-sectional study to detect carbapenem-resistant at 10 sentinel hospitals in Havana, Cuba for a six year-period (2016-2021) by the National Reference Laboratory for Health Care-Associated Infections in the Pedro Kourí Institute. A total of 152 isolates were collected with phenotypic production of metallo-β-lactamase. NDM-type carbapenemase was detected in all the 152 isolates, and KPC-type enzyme gene was simultaneously identified in four NDM-positive isolates. The most abundant carbapenemase-producing (CPE) species was (69.7%), followed by complex (13.2%), and (5.9%). Over the study period, among CPE, prevalence of was almost constant, while spp. showed slightly increasing tendency. The urinary tract (36.2%) was the most prevalent source of infection with CPE, followed by bloodstream (26.3%) and surgical wound (17.1%), being frequently derived from Intensive Care Units (35.5%) and urology wards (21.7%). This study revealed the present situation of CPE in hospitals in Havana, Cuba, showing the emergence and dissemination of producing NDM-type carbapenemase, mainly .
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11040514