Development of a Novel Design of Microfluidic Impedance Cytometry for Improved Sensitivity and Cell Identification

A long-standing issue for microfluidic impedance cytometry devices is the accuracy in determining the size of cells during counting and measurements. In this paper, we introduce a novel design that produces a homogeneous electric field in the sensing region and demonstrates higher accuracy than trad...

Full description

Saved in:
Bibliographic Details
Published in:ACS omega 2023-05, Vol.8 (21), p.18882-18890
Main Authors: Warren, Michael A., Shakouri, Amir, Pacheco-Peña, Víctor, Hallam, Toby
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A long-standing issue for microfluidic impedance cytometry devices is the accuracy in determining the size of cells during counting and measurements. In this paper, we introduce a novel design that produces a homogeneous electric field in the sensing region and demonstrates higher accuracy than traditional designs in cell counting and sizing, reducing the reliance on cell focusing and signal postprocessing. The concept is validated, and the increased accuracy of the device over traditional designs is demonstrated through the use of finite element simulations to generate suitable data sets for particle trajectories and model expected signal variations.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.3c00797