Effect of antimicrobials administered via liquid feed on the occurrence of sulphonamide and trimethoprim resistant Enterobacteriaceae: case-control study

Drugs for the treatment of groups of pigs receiving liquid feed are frequently mixed into the feed and administered via the pipelines of the feeding installations. In-feed antimicrobials may select antimicrobial resistant strains among the bacteria which form the biofilm of these pipelines and are s...

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Bibliographic Details
Published in:Porcine Health Management. 2017-10, Vol.3 (1), p.20-20, Article 20
Main Authors: Heller, Oliver, Stephan, Roger, Thanner, Sophie, Hässig, Michael, Bee, Giuseppe, Gutzwiller, Andreas, Sidler, Xaver
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
Biofilms
Disease prevention
Drug resistance
E coli
Enterobacteriaceae
Farms
Feeds
Food
Genes
Liquid feeding
Microorganisms
Oral group therapy
Sulphonamide
Trimethoprim
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Summary:Drugs for the treatment of groups of pigs receiving liquid feed are frequently mixed into the feed and administered via the pipelines of the feeding installations. In-feed antimicrobials may select antimicrobial resistant strains among the bacteria which form the biofilm of these pipelines and are shed into the liquid feed. In order to evaluate the risk of selecting antimicrobial resistant bacteria in the biofilm of liquid feeding installations, the effect of the administration of antimicrobials via the pipelines on the occurrence of antimicrobial resistance in the feed was examined in a case-control study. A premix containing either sulphonamide plus trimethoprim or sulphonamide plus chlortetracycline plus tylosin or chlortetracycline was administered via the pipelines to each batch of bought-in fattening pigs in 7, 3 and 3 case farms respectively, whereas antimicrobials had not been administered via the liquid feeding installation for at least 2 years in the 14 control farms. Enterobacteriaceae and sulphonamide-trimethoprim resistant Enterobacteriaceae were counted in twelve and eight feed samples collected in each case and in each control farm respectively during one fattening period. The semiparametric Generalized Estimating Equations (GEE) method was used for the statistical data analysis. The ratio of sulphonamide and trimethoprim resistant to total Enterobacteriaceae was higher in the feed of the case farms compared to the control farms (  
ISSN:2055-5660
2055-5660
DOI:10.1186/s40813-017-0067-0