Self‐assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic‐resistant bacteria

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria‐specific delivery of clinical antibiotic ciprofloxacin (CIP) and classic nanoantibiotic silver nanopart...

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Bibliographic Details
Published in:Aggregate (Hoboken) 2024-02, Vol.5 (1), p.n/a
Main Authors: Wu, Tiantian, Fu, Yu, Guo, Shuang, Shi, Yanqiang, Zhang, Yuxin, Fan, Zhijin, Yang, Bin, Ding, Baoquan, Liao, Yuhui
Format: Article
Language:English
Subjects:
antibiotic resistance
Antibiotics
anti‐infection therapy
Bacteria
Bacterial infections
Biocompatibility
biofilm
Composite materials
DNA nanotechnology
Drug resistance
E coli
Infections
Infectious diseases
Lignin
Nanoparticles
Nanotechnology
Physiology
targeted delivery
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Summary:Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria‐specific delivery of clinical antibiotic ciprofloxacin (CIP) and classic nanoantibiotic silver nanoparticles (AgNP). In our rational design, CIP was efficiently loaded in the self‐assembly double‐bundle DNA tetrahedron through intercalation with DNA duplex, and single‐strand DNA‐modified AgNP was embedded in the cavity of the DNA tetrahedron through hybridization. With the site‐specific assembly of targeting aptamer in the well‐defined DNA tetrahedron, the bacteria‐specific dual‐antibiotic delivery system exhibited excellent combined bactericidal properties. With enhanced antibiotic accumulation through breaking the out membrane of bacteria, the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in vivo. This DNA‐based antibiotic delivery system provides a promising strategy for the treatment of antibiotic‐resistant infections. A self‐assembly DNA tetrahedron‐based antibiotic delivery system with precisely organized bacteria‐specific aptamer was constructed to achieve targeted delivery of clinical antibiotic ciprofloxacin and classic nanoantibiotic silver nanoparticles for the efficient therapy of resistant infection.
ISSN:2692-4560
2766-8541
2692-4560
DOI:10.1002/agt2.402