Angioedema and Fatty Acids

Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioede...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-08, Vol.22 (16), p.9000
Main Authors: Wada, Akane, Sawada, Yu, Sugino, Hitomi, Nakamura, Motonobu
Format: Article
Language:English
Subjects:
Angioedema
Blood vessels
Bradykinin
Edema
Estrogens
Fatty acids
hereditary angioedema
Histamine
Human body
Mutation
Pathogenesis
Permeability
Physiology
Proteins
Review
Urticaria
Vasodilation
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Summary:Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22169000