Is 70Zn(d,x)67Cu the Best Way to Produce 67Cu for Medical Applications?

The pair of copper radionuclides 64 Cu/ 67 Cu (T 1/2 = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of 67 Cu with charged particles was performed and the reaction 70 Zn(d,x) route was identified as a promising one. It may...

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Bibliographic Details
Published in:Frontiers in medicine 2021-07, Vol.8, p.674617-674617
Main Authors: Nigron, Etienne, Guertin, Arnaud, Haddad, Ferid, Sounalet, Thomas
Format: Article
Language:English
Subjects:
67Cu
accelerators
cross section
deuteron reactions
Medicine
production
theranostic
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Summary:The pair of copper radionuclides 64 Cu/ 67 Cu (T 1/2 = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of 67 Cu with charged particles was performed and the reaction 70 Zn(d,x) route was identified as a promising one. It may allow the production of 67 Cu without 64 Cu. The production cross section has been measured up to 28.7 MeV. Measurements were done using the well-known stacked-foils technique using 97.5% enriched 70 Zn homemade electroplated targets. These measurements complement at higher incident energies the only set of data available in nuclear databases. The results show that using a 26 MeV deuteron beam and a highly enriched 70 Zn target, it is possible to produce high purity 67 Cu comparable to that obtained using photoproduction. This production route can be of interest for future linear accelerators under development where mA deuteron beams can be available if adequate targetry is developed.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.674617