The Impact of Diet and Exercise on Drug Responses

It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in cardiovascular diseases. However, the physiological changes induced by exercise and a modified diet also have the capa...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-07, Vol.22 (14), p.7692
Main Authors: Niederberger, Ellen, Parnham, Michael J.
Format: Article
Language:English
Subjects:
Bioavailability
Body composition
Cardiovascular diseases
Clinical trials
Cytochrome
Diabetes
Diet
Dietary minerals
drug
Drug interactions
Drug therapy
Drugs
Enzymes
Exercise
Food
Influence
Liver
Metabolism
Mutation
Obesity
Pharmacodynamics
Pharmacokinetics
Pharmacology
Physical fitness
Physiological effects
Physiology
Proteins
Review
Signal transduction
Toxicity
Vitamins
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Summary:It is well known that lifestyle changes can alter several physiological functions in the human body. For exercise and diet, these effects are used sensibly in basic therapies, as in cardiovascular diseases. However, the physiological changes induced by exercise and a modified diet also have the capacity to influence the efficacy and toxicity of several drugs, mainly by affecting different pharmacokinetic mechanisms. This pharmacological plasticity is not clinically relevant in all cases but might play an important role in altering the effects of very common drugs, particularly drugs with a narrow therapeutic window. Therefore, with this review, we provide insights into possible food–drug and exercise–drug interactions to sharpen awareness of the potential occurrence of such effects.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22147692