Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function

Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system, and normal development. Many epidemiological cohort studies globally have found high prevalence rates of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2022-05, Vol.13, p.860286
Main Authors: Lundy, Kassidy, Greally, John F, Essilfie-Bondzie, Grace, Olivier, Josephine B, Doña-Termine, Reanna, Greally, John M, Suzuki, Masako
Format: Article
Language:English
Subjects:
Animals
DOHaD (developmental origins of health and disease)
Endocrinology
Endothelial Cells - metabolism
Female
Humans
liver
Liver - metabolism
Male
Mice
Mice, Inbred C57BL
Pregnancy
prenatal environment
transcriptional alterations
Vitamin D - metabolism
vitamin D deficiency
Vitamin D Deficiency - epidemiology
Vitamins
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Summary:Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system, and normal development. Many epidemiological cohort studies globally have found high prevalence rates of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be solved. In particular, reproductive age and pregnant women low in vitamin D status may confer risks of diseases like obesity on their offspring. While observational studies have suggested associations between prenatal vitamin D deficiency and metabolic phenotypes in offspring, not yet determined is whether prenatal vitamin D deficiency permanently alters the development of the liver, a major metabolic organ. We tested the histopathology and the transcriptomic profiles of livers from male C57BL/6J mice exposed to prenatal vitamin D deficiency through a maternal dietary intervention model. We found that prenatal vitamin D deficiency increases the prevalence of histopathological changes in the liver, and alters its gene expression profile. Cell subtype proportion analysis showed that the liver of prenatal vitamin D deficiency alters non-parenchymal cells of the liver, specifically macrophages, a subset of endothelial cells, and dendritic cells. Our results indicate the long-term memory of prenatal vitamin D deficiency exposure in the adult liver, a potential contributor to offspring health risks.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.860286