Iron in Cardiovascular Disease: Challenges and Potentials

Iron is essential for many biological processes. Inadequate or excess amount of body iron can result in various pathological consequences. The pathological roles of iron in cardiovascular disease (CVD) have been intensively studied for decades. Convincing data demonstrated a detrimental effect of ir...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2021-11, Vol.8, p.707138-707138
Main Authors: Li, Shizhen, Zhang, Xiangyu
Format: Article
Language:English
Subjects:
cardiovascular disease
Cardiovascular Medicine
ferroptosis
iron
iron chelation
iron overload
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Summary:Iron is essential for many biological processes. Inadequate or excess amount of body iron can result in various pathological consequences. The pathological roles of iron in cardiovascular disease (CVD) have been intensively studied for decades. Convincing data demonstrated a detrimental effect of iron deficiency in patients with heart failure and pulmonary arterial hypertension, but it remains unclear for the pathological roles of iron in other cardiovascular diseases. Meanwhile, ferroptosis is an iron-dependent cell death that is distinct from apoptosis, necroptosis, and other types of cell death. Ferroptosis has been reported in several CVDs, namely, cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy seems to be an available strategy to ameliorate iron overload-related disorders. It is still a challenge to accurately clarify the pathological roles of iron in CVD and search for effective medical intervention. In this review, we aim to summarize the pathological roles of iron in CVD, and especially highlight the potential mechanism of ferroptosis in these diseases.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2021.707138