Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report

Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in ch...

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Published in:Mediators of Inflammation 2012-01, Vol.2012 (2012), p.561-570-162
Main Authors: Warwas, Maria, Simon, Krzysztof, Pazgan-Simon, Monika, Zuwała-Jagiełło, Jolanta
Format: Article
Language:English
Subjects:
Adult
Aged
C-Reactive Protein - metabolism
Clinical Study
Female
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - metabolism
Humans
Male
Middle Aged
Picolinic Acids - blood
Young Adult
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container_end_page 570-162
container_issue 2012
container_start_page 561
container_title Mediators of Inflammation
container_volume 2012
creator Warwas, Maria
Simon, Krzysztof
Pazgan-Simon, Monika
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description Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P
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Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P&lt;0.01 and P&lt;0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P&lt;0.01). The positive relationships were between PA and hsCRP levels (P&lt;0.05) and the presence of diabetes (P&lt;0.001). 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Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P&lt;0.01 and P&lt;0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P&lt;0.01). 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subjects Adult
Aged
C-Reactive Protein - metabolism
Clinical Study
Female
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - metabolism
Humans
Male
Middle Aged
Picolinic Acids - blood
Young Adult
title Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report
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