Mandibular Endochondral Growth Is Specifically Augmented by Nutritional Supplementation with Myo-Inositol Even in Rabbits

Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of...

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Bibliographic Details
Published in:Dentistry journal 2024-02, Vol.12 (3), p.49
Main Authors: Shimoyama, Miho, Kanzaki, Hiroyuki, Tohyama, Syunnosuke, Ida, Tomomi, Ishikawa, Misao, Katsumata, Yuta, Arai, Chihiro, Wada, Satoshi, Manase, Shugo, Tomonari, Hiroshi
Format: Article
Language:English
Subjects:
Analysis
Animal experimentation
Animal research
Cartilage
endochondral growth
Experiments
Feed additives
Femur
functional appliances
Growth
Health aspects
Image analysis
Image processing
Inositol
Inositols
Kinases
Laboratory animals
Mandible
mandibular condylar cartilage
mandibular retrognathism
Mastication
myo-inositol
Orthodontics
Patients
Pediatrics
pik3cd
Rabbits
Sleep apnea
Tomography
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Summary:Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of functional appliances is not always stable in daily practices. A more effective, reliable, and safer therapeutic method for mandibular growth promotion would be helpful for growing mandibular retrognathism patients. As we previously discovered that nutritional supplementation of myo-inositol in growing mice specifically increases mandibular endochondral growth, we performed preclinical animal experiments in rabbits in this study. Briefly, six-week-old male Japanese white rabbits were fed with or without myo-inositol supplementation in laboratory chow until 25 weeks old, and 3D image analysis using micro CT data and histological examinations was done. Myo-inositol had no systemic effect, such as femur length, though myo-inositol specifically augmented the mandibular growth. Myo-inositol increased the thickness of mandibular condylar cartilage. We discovered that the nutritional supplementation of myo-inositol during the growth period specifically augmented mandibular growth without any systemic influence, even in rabbits. Our results suggest the possibility of clinical use of myo-inositol for augmentation of the mandibular growth in growing mandibular retrognathism patients in the future.
ISSN:2304-6767
2304-6767
DOI:10.3390/dj12030049