Sexually dimorphic neuronal responses to social isolation

Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifica...

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Bibliographic Details
Published in:eLife 2016-10, Vol.5
Main Authors: Senst, Laura, Baimoukhametova, Dinara, Sterley, Toni-Lee, Bains, Jaideep Singh
Format: Article
Language:English
Subjects:
Action Potentials
Analysis
Animals
Corticosterone
Corticotropin-Releasing Hormone - secretion
Excitability
Experiments
Females
Gender differences
Glucocorticoids
ion channels
Latency
Males
Mice
Neurons
Neurons - physiology
Neuroscience
Paraventricular Hypothalamic Nucleus - physiology
Physiological aspects
plasticity
Rodents
sex differences
Sex Factors
Sexual dimorphism
Social aspects
Social interactions
Social Isolation
Social networks
Social organization
stress
Stress (Psychology)
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Summary:Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifically, isolating preadolescent female mice from littermates for
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.18726