Achievements and beyond: Scientific trajectory of Professor Mohammad A. Rafi

[...]we should be ready for subtle changes, no matter what. [...]he studied the interaction of prolactin and thyroxin on the development of the thyroid gland in Xenopus laevis, which resulted in an innovative method of organotypic culture of the thyroid gland of this amphibian. In 1987, he joined Pr...

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Bibliographic Details
Published in:Bioimpacts 2021-01, Vol.11 (1), p.1-4
Main Authors: Omidi, Yadollah, Alavi, Abass
Format: Article
Language:English
Subjects:
Bone marrow
Bone marrow transplantation
Disease
Editorials
Gene therapy
Genetics
krabbe disease
Laboratories
lysosomal storage disorders
Molecular biology
Neurology
Parasitology
Prolactin
Sabbatical leave
Science
Stem cells
Thyroid
Thyroid gland
Thyroxine
Vectors (Biology)
Xenografts
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Summary:[...]we should be ready for subtle changes, no matter what. [...]he studied the interaction of prolactin and thyroxin on the development of the thyroid gland in Xenopus laevis, which resulted in an innovative method of organotypic culture of the thyroid gland of this amphibian. In 1987, he joined Professor David Wenger's research group at Jefferson Medical College, Department of Medicine, Division of Medical Genetics, at TJU. The successful outcome of each of these ideas was a turning point in the research on the treatment of the Twi mice. * In 2015, the combination of gene therapy using AAVrh10 expressing GALC cDNA following bone marrow transplantation resulted in unprecedented outcomes in the treatment of the Twi mice.29 This combinational method of treatment is currently under investigation by the National Institutes of Health (NIH) for a human trial. * In 2020, he demonstrated the importance of viral dose in combinational therapy.19 As for publications and presentations, his research accomplishments have resulted in over 80 peer-reviewed articles and book chapters as an author and co-author.
ISSN:2228-5660
2228-5652
2228-5660
DOI:10.34172/bi.2021.01