Low energy nanoemulsions as carriers for essential oils in topical formulations for antioxidant skin protection

In this study several essential oils (EOs): basil - BA, lemon balm - LB and oregano - OR were incorporated into nanoemulsions (NEs) as prospective carriers for natural and sensitive bioactives. NEs were prepared via the phase inversion composition (PIC) method, which is an energy-efficient cold proc...

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Bibliographic Details
Published in:Hemijska industrija 2022-01, Vol.76 (1), p.29-42
Main Authors: Gledovic, Ana, Bajuk-Bogdanovic, Danica, Uskokovic-Markovic, Snezana, Pavun, Leposava, Savic, Snezana, Lezaic, Aleksandra Janosevic
Format: Article
Language:English
Subjects:
Antioxidants
Aqueous solutions
basil
Care and treatment
Electrical resistivity
Emulsions
Essences and essential oils
Essential oils
Formulations
Health aspects
lemon balm
Nanoemulsions
nanonisation
Nanoparticles
Oils & fats
Optical microscopy
Oregano
Particle size distribution
Raman spectra
raman spectroscopy
Skin
stability
Stability analysis
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Summary:In this study several essential oils (EOs): basil - BA, lemon balm - LB and oregano - OR were incorporated into nanoemulsions (NEs) as prospective carriers for natural and sensitive bioactives. NEs were prepared via the phase inversion composition (PIC) method, which is an energy-efficient cold process. Physicochemical stability of NEs was confirmed by particle size distribution analysis, electrical conductivity and pH value measurements, as well as by optical microscopy observations. The type of EO and the surfactant and oil mix concentration were found to be crucial factors governing the NE properties and stability. Raman spectra of the EOs confirmed main active ingredients and provided detection of interactions with the nanocarrier, which is a novel application of this technique. The antioxidant activity towards DPPH radical in methanol was concentration-dependent with a similar trend for individual oils and oil-loaded NEs (OR> LB> BA). However, the ABTS test in an aqueous medium revealed notable change in the order of activity after EO nanonisation at higher EO concentrations. Overall, it was found that OR-NE was the most effective and stable system, since OR acted as a co-stabiliser in the NE formulation, and its remarkably high antioxidant activity was successfully preserved during 6 months of storage.
ISSN:0367-598X
2217-7426
DOI:10.2298/HEMIND210509004G