Genetic Characterization of African Swine Fever Virus from Pig Farms in South Korea during Outbreaks in 2019-2021

In South Korea, a total of 21 African swine fever (ASF) infected farms were confirmed during 2019-2021. ASF viruses (ASFVs) were isolated from the blood and spleen samples of the 21 affected farms and their genetic characteristics were analyzed. Phylogenetic analysis indicated that the 21 Korean ASF...

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Bibliographic Details
Published in:Viruses 2022-11, Vol.14 (12), p.2621
Main Authors: Cho, Ki-Hyun, Kim, Da-Young, Jang, Min-Kyung, Hong, Seong-Keun, Ryu, Ji-Hyoung, Kang, Hae-Eun, Park, Jee-Yong
Format: Article
Language:English
Subjects:
African swine fever
African Swine Fever - epidemiology
African Swine Fever Virus
Amino acids
Animals
Antibodies
Brief Report
Diagnosis
Disease Outbreaks - veterinary
Epidemics
Farms
Genes
Genetic analysis
Genetic aspects
genetic characterization
Genomes
Genotype
Genotype & phenotype
Genotypes
Hogs
Laboratories
Livestock industry
Management
Nucleotide sequence
Phylogenetics
Phylogeny
pig farms
Republic of Korea - epidemiology
South Korea
Strains (organisms)
Sus scrofa
Swine
Tyrosine
Vaccines
Variable region
virus isolation
Viruses
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Summary:In South Korea, a total of 21 African swine fever (ASF) infected farms were confirmed during 2019-2021. ASF viruses (ASFVs) were isolated from the blood and spleen samples of the 21 affected farms and their genetic characteristics were analyzed. Phylogenetic analysis indicated that the 21 Korean ASFV strains belonged to p72 genotype II and serogroup 8. All isolates were of the intergenic region (IGR) II variant with 10 tandem repeat sequences between I73R and I329L and the central variable region (CVR) 1 variant of the B602L gene. There were no IGR variations between the A179L and A137R and between the MGF 505 9R and10R nor mutations in the O174L, K145R, MGF 505-5R, CP204L, and Bt/Sj regions. The genes of the 21 ASFV strains were identical to those of Georgia 2007/1 and Chinese and Vietnamese strains (Pig/HLJ/2018, China/2018/AnhuiXCGQ, and ASFV_NgheAn_2019); however, X69R of the J268L region of the 18th isolate (Korea/Pig/Goseong/2021) had three nucleotide (CTA) insertions at the 209th position, which led to the addition of one tyrosine (Y) at the C-terminal. This suggests that there are variations among ASFVs circulating in South Korea and the 18th ASFV-infected farm was due to a variant different from those of the other 20 pig farms.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14122621