Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

• Published in: Molecules (Basel, Switzerland) Switzerland), 2023-07, Vol.28 (15), p.5645
• Main Authors: Fang, Xiaolei, Song, Jiayu, Zhou, Kaixuan, Zi, Xue, Sun, Bin, Bao, Huiwei, Li, Lijing
• Format: Article
• Language: English
• Subjects: Antioxidants; Care and treatment; Cytokines; Enzymes; Fatty acids; Fatty liver; Flavonoids; Health aspects; hepatic steatosis; Homeostasis; Humans; Inflammation; Inflammation - metabolism; Insulin Resistance; Lipids; Liver; Liver diseases; Metabolism; Metabolites; Microbiota; Microbiota (Symbiotic organisms); natural compounds; non-alcoholic fatty liver disease; Non-alcoholic Fatty Liver Disease - metabolism; Oxidation; Oxidative Stress; Pathogenesis; Proteins; Review; Sterols; Transcription factors; Transforming growth factors; Tumor necrosis factor-TNF; Type 2 diabetes
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28155645

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and its incidence continues to increase each year. Yet, there is still no definitive drug that can stop its development. This review focuses mainly on lipotoxicity, oxidative stress, inflammation, and intestinal flora dysbiosis to understand NAFLD's pathogenesis. In this review, we used NCBI's PubMed database for retrieval, integrating in vivo and in vitro experiments to reveal the therapeutic effects of natural compounds on NAFLD. We also reviewed the mechanisms by which the results of these experiments suggest that these compounds can protect the liver from damage by modulating inflammation, reducing oxidative stress, decreasing insulin resistance and lipid accumulation in the liver, and interacting with the intestinal microflora. The natural compounds discussed in these papers target a variety of pathways, such as the AMPK pathway and the TGF-β pathway, and have significant therapeutic effects. This review aims to provide new possible therapeutic lead compounds and references for the development of novel medications and the clinical treatment of NAFLD. It offers fresh perspectives on the development of natural compounds in preventing and treating NAFLD.