Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study

Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270...

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Bibliographic Details
Published in:Children (Basel) 2022-09, Vol.9 (10), p.1421
Main Authors: Ota, Takeshi, Mori, Jun, Kawabe, Yasuhiro, Morimoto, Hidechika, Fukuhara, Shota, Kodo, Kazuki, Sugimoto, Satoru, Kosaka, Kitaro, Nakajima, Hisakazu, Hosoi, Hajime
Format: Article
Language:English
Subjects:
Age
brown adipose tissue
Cholesterol
Diabetes in children
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Middle schools
Multivariate analysis
Obesity
Observations
Overweight
Pathogenesis
pediatric obesity
Pediatrics
Statistical analysis
Thermogenesis
type 2 deiodinase
uncoupling protein 1
β3 adrenergic receptor
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Summary:Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (p = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala.
ISSN:2227-9067
2227-9067
DOI:10.3390/children9101421