Efficacy of an experimental toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride on gingivitis

Gingivitis is driven by plaque accumulation and, if left untreated, can progress to irreversible periodontitis. For many, the mechanical action of toothbrushing does not achieve adequate plaque control. The aim of this study was to investigate whether twice-daily use of a toothpaste containing 0.2%...

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Bibliographic Details
Published in:BMC oral health 2024-02, Vol.24 (1), p.209-209, Article 209
Main Authors: Axe, Alyson, Patel, Nisha, Qaqish, Jimmy, Ling, Martin R, Araga, Mako, Parkinson, Charlie, Goyal, Chaju Ram
Format: Article
Language:English
Subjects:
Bleeding
Clinical medicine
Dentifrices
Fluoride treatments
Fluorides
Gingiva
Gingival index
Gingivitis
Gum disease
Hyaluronic acid
Inflammation
Molecular weight
Orthodontics
Periodontitis
Plaque
Plaque index
Sodium
Sodium bicarbonate
Sodium fluoride
Sodium hyaluronate
Teeth
Toothbrushes
Toothbrushing
Toothpaste
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Summary:Gingivitis is driven by plaque accumulation and, if left untreated, can progress to irreversible periodontitis. For many, the mechanical action of toothbrushing does not achieve adequate plaque control. The aim of this study was to investigate whether twice-daily use of a toothpaste containing 0.2% high molecular weight (HMW) sodium hyaluronate with 67% sodium bicarbonate and 0.221% sodium fluoride (experimental toothpaste) could improve gingival health compared with a regular fluoride toothpaste (negative control). The study also assessed whether the experimental toothpaste could provide additive gingival health benefit over a toothpaste containing only 67% sodium bicarbonate and 0.221% sodium fluoride (positive control). This was a single-center, examiner-blinded, randomized, clinical study in healthy adults with mild-to-moderate gingivitis. At baseline, after abstaining from toothbrushing for 12 h, prospective participants underwent oral soft tissue (OST) and oral hard tissue examination followed by assessments for gingival inflammation (Modified Gingival Index [MGI]), gingival bleeding (Bleeding Index [BI]), and supra-gingival plaque (Turesky Plaque Index [TPI]). Eligible participants were stratified by gender and baseline number of bleeding sites (low:
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-024-03981-9