Prognostic significance of pretreatment lymphocyte/monocyte ratio in retroperitoneal liposarcoma patients after radical resection

The aim of this study was to evaluate the prognostic value of pretreatment inflammatory biomarkers in retroperitoneal liposarcoma (RPLS) patients after radical resection. One hundred patients with RPLS who underwent radical resection between September 2004 and October 2010 at Fudan University Shangh...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.4727-4734
Main Authors: Luo, Peng, Cai, Weiluo, Yang, Lingge, Chen, Shiqi, Wu, Zhiqiang, Chen, Yong, Zhang, Ruming, Shi, Yingqiang, Yan, Wangjun, Wang, Chunmeng
Format: Article
Language:English
Subjects:
Biological markers
Cancer
Cancer research
Cancer therapies
Chemotherapy
Colorectal cancer
Family medical history
Gastric cancer
Inflammation
inflammatory biomarkers
Laboratories
Liposarcoma
Lung cancer
lymphocyte/monocyte ratio
Lymphocytes
Medical prognosis
Metastasis
Neutrophils
Original Research
Patients
prognosis
Radiation therapy
Retroperitoneal liposarcoma
Statistical analysis
Surgery
Tumors
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Summary:The aim of this study was to evaluate the prognostic value of pretreatment inflammatory biomarkers in retroperitoneal liposarcoma (RPLS) patients after radical resection. One hundred patients with RPLS who underwent radical resection between September 2004 and October 2010 at Fudan University Shanghai Cancer Center were included in this study. Laboratory tests of peripheral blood were sampled before surgery. The optimal cutoff values of systemic inflammatory markers were defined by receiver-operating curve analyses. Curves of disease-free survival (DFS) and overall survival (OS) were obtained by the Kaplan-Meier method. Cox proportional hazards regression modeling was used to perform univariate and multivariate analyses. The median follow-up time was 53 months. The median DFS and OS were 27 and 86 months, respectively. On the basis of the optimal cutoff value of 3, 24 patients were classified into low lymphocyte/monocyte ratio (LMR) group and 76 patients into high LMR group. In univariate analysis, low LMR group had significantly shorter DFS (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S171602