Microfluidics chips fabrication techniques comparison

This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethy...

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Bibliographic Details
Published in:Scientific reports 2024-11, Vol.14 (1), p.28793-13, Article 28793
Main Authors: Liu, Xiaocheng, Sun, Antao, Brodský, Jan, Gablech, Imrich, Lednický, Tomáš, Vopařilová, Petra, Zítka, Ondřej, Zeng, Wen, Neužil, Pavel
Format: Article
Language:English
Subjects:
3-D printers
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639/166/985
Ablation
Biocompatibility
Comparative analysis
COVID-19
COVID-19 - virology
Dimethylpolysiloxanes - chemistry
Equipment Design
Fabrication
Flexibility
Heat conductivity
Humanities and Social Sciences
Humans
Injection molding
Integrated circuits
Lab-On-A-Chip Devices
Lasers
Methods
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidics
Microfluidics - instrumentation
Microfluidics - methods
Micromachining
multidisciplinary
Pandemics
Point of care testing
Polydimethylsiloxane
Polyethylene terephthalate
Polymethyl methacrylate
Polymethyl Methacrylate - chemistry
Polymethylmethacrylate
Rapid prototyping
SARS-CoV-2 - isolation & purification
Science
Science (multidisciplinary)
Silicon
Stainless steel
Thermal cycling
Thermal properties
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Summary:This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethyl methacrylate, soft lithography for polydimethylsiloxane-based devices, xurography for glass-glass chips, and micromachining-based silicon-glass chips, we analyze each technique’s strengths and trade-offs. Hence, we discuss the fabrication complexity and chip thermal properties, such as heating and cooling rates, which are essential features of chip utilization for a polymerase chain reaction. Our comparative analysis reveals critical insights into material challenges, design flexibility, and cost-efficiency, aiming to guide the development of robust and reliable microfluidic devices for healthcare and research. This work underscores the importance of selecting appropriate fabrication methods to optimize device functionality, durability, and production efficiency.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-80332-2