Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil

We report on the first isolation of dengue virus serotype 4 (DENV-4) in the State of Mato Grosso do Sul, Brazil, in February, 2012. The cases were isolated in the city of Campo Grande, the state capital, and presented the classic signs and symptoms of dengue fever. DENV-4 was primarily identified th...

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Bibliographic Details
Published in:Cadernos de saúde pública 2014-08, Vol.30 (8), p.1789-1792
Main Authors: Bertolacci-Rocha, Lívia Garcia, Cunha, Rivaldo Venâncio da, Lichs, Gislene Garcia de Castro, Dal Fabbro, Márcia Maria Ferrairo Janini, Motta-Castro, Ana Rita Coimbra
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brazil - epidemiology
Dengue
Dengue - epidemiology
Dengue - virology
Dengue Virus - genetics
Dengue Virus - isolation & purification
Enfermedades Trasmisibles
Female
Humans
Male
Middle Aged
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Reverse Transcriptase Polymerase Chain Reaction
Virus del Dengue
Young Adult
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Summary:We report on the first isolation of dengue virus serotype 4 (DENV-4) in the State of Mato Grosso do Sul, Brazil, in February, 2012. The cases were isolated in the city of Campo Grande, the state capital, and presented the classic signs and symptoms of dengue fever. DENV-4 was primarily identified through viral isolation in C6/36 clone lineage of Aedes albopictus cells; followed by indirect immunofluorescence, using type-specific monoclonal antibodies. The results were subsequently confirmed by Nested RT-PCR tests. The first description of the introduction of DENV-4 in a state whose population is susceptible to this serotype and the circulation of three other serotypes in the area is cause for concern due to the increased possibility of severe and lethal cases of the disease, and of huge epidemics.
ISSN:0102-311X
1678-4464
1678-4464
0102-311X
DOI:10.1590/0102-311X00003914