A Synthetic Model of the Mucosa for Oral Penetration Studies

The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to water was compared. Moreove...

Full description

Saved in:
Bibliographic Details
Published in:Membranes (Basel) 2023-12, Vol.13 (12), p.905
Main Authors: Alonso, Cristina, Martí, Meritxell, Ramos, Anderson, Calpena, Ana Cristina, Clares-Naveros, Beatriz, Coderch, Luisa
Format: Article
Language:English
Subjects:
Analysis
Biocides
Caffeine
Drugs
Epithelium
Ethics
Formulations
in vitro permeation
Laboratory animals
Lipids
Membrane permeability
Membranes
Molecular weight
Mucosa
mucosa membrane
Mucous membrane
Oral mucosa
Penetration
Permeability
Permeation
Pharmaceuticals
Physiology
Screening
synthetic membrane
TMWL
Toxins
Water loss
Waterproofing
waterproofing formulations
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to water was compared. Moreover, the water permeability of membranes modified with waterproofing formulations was measured to study their ability to protect against the penetration of viruses, toxins, etc. A relatively high correlation (R 0.88) was obtained between the transmucosal water loss (TMWL) values of the artificial membrane and the mucosa. These results support the possible use of this synthetic membrane in the screening of the water permeability of formulations. In addition, studies of the permeation of different actives, drugs, and biocides through the two membranes were carried out, and these results were compared with their skin permeation data. The synthetic membrane does not seem to discern between compounds in terms of permeability. However, the permeation of caffeine through intact or modified membranes incorporating waterproofing formulations presents similar permeation profiles through the synthetic membrane and mucosa. The results from these assays should lend support to the use of this synthetic membrane when screening formulations to be applied in oral penetration studies.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes13120905