The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activat...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-06, Vol.15 (6), p.767
Main Authors: Afrasiabi, Shima, Partoazar, Alireza, Chiniforush, Nasim, Goudarzi, Ramin
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Antioxidants
Bacteria
Biofilms
Dental caries
dental infection control
Drug resistance
Fibroblasts
Free radicals
Gene expression
Infectious diseases
Light emitting diodes
Microorganisms
nanoparticles
photochemotherapy
Photodynamic therapy
photosensitizing agents
Review
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, chlorella, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15060767