Antimicrobial Susceptibility of Ertapenem in Neisseria gonorrhoeae Isolates Collected Within the China Gonococcal Resistance Surveillance Programme (China-GRSP) 2018

This study aimed to determine the minimum inhibitory concentrations (MICs) of ertapenem on collected from eight Chinese provinces in 2018. The MICs of ertapenem on 503 isolates (415 isolates selected randomly and 88 isolates selected with preference) were measured using the agar dilution method. For...

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Bibliographic Details
Published in:Infection and drug resistance 2021-01, Vol.14, p.4183-4189
Main Authors: Xu, Wen-Qi, Zheng, Xiao-Li, Liu, Jing-Wei, Zhou, Qian, Zhu, Xiao-Yu, Zhang, Jin, Han, Yan, Chen, Kai, Chen, Shao-Chun, Chen, Xiang-Sheng, Yin, Yue-Ping
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
antimicrobial resistance
Azithromycin
Ceftriaxone
Dermatology
Drug resistance
Ertapenem
Gonorrhea
Infections
Minimum inhibitory concentration
Neisseria gonorrhoeae
Original Research
Provinces
Regression analysis
Sexually transmitted diseases
STD
Surveillance
treatment
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Summary:This study aimed to determine the minimum inhibitory concentrations (MICs) of ertapenem on collected from eight Chinese provinces in 2018. The MICs of ertapenem on 503 isolates (415 isolates selected randomly and 88 isolates selected with preference) were measured using the agar dilution method. For comparison, the MICs of ceftriaxone and azithromycin were detected. Among 415 randomly selected isolates, the MIC range for ertapenem was from ≤0.008 mg/L to 0.5 mg/L. The corresponding MIC and MIC were 0.06 and 0.125 mg/L, respectively. Twelve of 415 isolates (2.9%) exhibited MIC values ≥0.25 mg/L, and only one isolate (0.2%) had a MIC of 0.5 mg/L. By comparing all 503 tested isolates, a correlation of = 0.487 (
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S335252