Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

Traumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of individuals globally. Once considered solely acute events, these neurological conditions are now recognized as enduring pathological processes with long-term consequences, including an increased susceptibilit...

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Bibliographic Details
Published in:Translational neurodegeneration 2024-12, Vol.13 (1), p.61-19, Article 61
Main Authors: Huang, Zhihai, Xu, Peisheng, Hess, David C, Zhang, Quanguang
Format: Article
Language:English
Subjects:
Animals
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - pathology
Cellular senescence
Cellular Senescence - physiology
Humans
Neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Review
Senolytic therapy
Stroke
Stroke - pathology
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of individuals globally. Once considered solely acute events, these neurological conditions are now recognized as enduring pathological processes with long-term consequences, including an increased susceptibility to neurodegeneration. However, effective strategies to counteract their devastating consequences are still lacking. Cellular senescence, marked by irreversible cell-cycle arrest, is emerging as a crucial factor in various neurodegenerative diseases. Recent research further reveals that cellular senescence may be a potential driver for secondary neurodegeneration following brain injury. Herein, we synthesize emerging evidence that TBI and stroke drive the accumulation of senescent cells in the brain. The rationale for targeting senescent cells as a therapeutic approach to combat neurodegeneration following TBI/stroke is outlined. From a translational perspective, we emphasize current knowledge and future directions of senolytic therapy for these neurological conditions.
ISSN:2047-9158
2047-9158
DOI:10.1186/s40035-024-00457-2