Biotechnological Intervention and Withanolide Production in Withania coagulans

Withania coagulans (Stocks) Dunal is used in traditional medicine to treat diseases and has numerous pharmacological properties due to its biological compounds. The plant is a subshrub native to Asia, especially the tropical and temperate regions of western Asia. Its medicinal effects derive from it...

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Published in:Agronomy (Basel) 2023-08, Vol.13 (8), p.1997
Main Authors: Ahmad, Zishan, Shaheen, Arjumend, Wasi, Adla, Rehman, Shams ur, Tahseen, Sabaha, Ramakrishnan, Muthusamy, Upadhyay, Anamica, Ganie, Irfan Bashir, Shahzad, Anwar, Ding, Yulong
Format: Article
Language:English
Subjects:
Asthma
Berries
Biological properties
Biotechnology
Biotechnology industry
Conservation
Cultivars
Diabetes mellitus
Endangered & extinct species
ethnomedicines
Flowers & plants
genetic engineering
Genetic transformation
Genomes
Germplasm
Hairy root
Herbal medicine
Medicine
Metabolites
Micropropagation
pharmacological activities
Phytochemicals
Polygamy
Production methods
secondary metabolites
Seeds
Steroids
tissue culture
transcriptomics
Withania coagulans
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Summary:Withania coagulans (Stocks) Dunal is used in traditional medicine to treat diseases and has numerous pharmacological properties due to its biological compounds. The plant is a subshrub native to Asia, especially the tropical and temperate regions of western Asia. Its medicinal effects derive from its biological components, which are linked to human health. Conventional medicine uses these compounds to treat a variety of diseases, such as neurological issues, diabetes, and asthma. The long-term benefits of W. coagulans necessitate conservation strategies and plant biotechnological techniques such as micropropagation, synthetic seed, cell suspension, and hairy root elicitation technology, and genetic transformation can all play significant roles in conservation and sustainable utilization of the biological compounds for clinical uses. The objective of this review is to provide a comprehensive overview of the W. cogaulans medicinal properties, potential applications, and innovative approaches for sustainable utilization, making it a unique contribution to the existing body of knowledge. Multi-omics methods for the production of withanolides were also examined in order to gain a better understanding of the genome structure, prospective genes, and candidate proteins involved in the production.
ISSN:2073-4395
2073-4395
DOI:10.3390/agronomy13081997