Amyloidosis of submandibular lymph node masquerading as a salivary gland tumor: A rare case report with review of literature

Amyloidosis is a disease characterized by the extracellular deposition of fibrillary proteins causing organ dysfunction. Submandibular lymphadenopathy is a rare clinical presentation of amyloidosis. Majority of the patients progress to develop systemic diseases and usually have AL amyloidosis. Here,...

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Published in:Journal of the scientific society (Belgaum) 2020-09, Vol.47 (3), p.188-191
Main Authors: Mukharji, Snigdha, Shruthi, K, Date, Amit, Sudhamani, S, Rao, Rajiv
Format: Article
Language:English
Subjects:
amyloidoma
Amyloidosis
Birefringence
Case reports
Diagnosis
Electrophoresis
Immunohistochemistry
Leukocytes (eosinophilic)
Literature reviews
Lymph nodes
Lymphadenopathy
Lymphatic system
Oral cancer
Proteins
Salivary gland
Salivary glands
Serum proteins
submandibular swelling
Swelling
Tumors
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creator Mukharji, Snigdha
Shruthi, K
Date, Amit
Sudhamani, S
Rao, Rajiv
description Amyloidosis is a disease characterized by the extracellular deposition of fibrillary proteins causing organ dysfunction. Submandibular lymphadenopathy is a rare clinical presentation of amyloidosis. Majority of the patients progress to develop systemic diseases and usually have AL amyloidosis. Here, we report a case of a 40-year-old male, who presented with a left submandibular swelling for 3 years. The clinical diagnosis was malignant submandibular salivary gland tumor. Systemic examination was unremarkable. Histopathological examination of the excised swelling revealed effacement of lymph node architecture by an eosinophilic Schiff poor material. Positive Congo red stain with apple-green birefringence on polarization confirmed it as amyloidosis. Serum protein electrophoresis was negative for M Band. Immunohistochemistry revealed kappa light-chain restriction in the deposits, characterizing it as localized primary amyloidosis of the submandibular lymph nodes.
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ispartof Journal of the scientific society (Belgaum), 2020-09, Vol.47 (3), p.188-191
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2278-7127
language eng
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subjects amyloidoma
Amyloidosis
Birefringence
Case reports
Diagnosis
Electrophoresis
Immunohistochemistry
Leukocytes (eosinophilic)
Literature reviews
Lymph nodes
Lymphadenopathy
Lymphatic system
Oral cancer
Proteins
Salivary gland
Salivary glands
Serum proteins
submandibular swelling
Swelling
Tumors
title Amyloidosis of submandibular lymph node masquerading as a salivary gland tumor: A rare case report with review of literature
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