Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic F...

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Published in:Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2022-12, Vol.50 (1), p.312-321
Main Authors: Khan, Ajmal, Jabeen, Humera, Ahmad, Touqeer, Rehman, Najeeb Ur, Khan, Saleha Suleman, Shareef, Huma, Sarwar, Rizwana, Yahya, Saira, Hussain, Nusrat, Uddin, Jalal, Hussain, Javid, Al-Harrasi, Ahmed
Format: Article
Language:English
Subjects:
antibiofilm
Atomic force microscopy
Biofilms
Cephradine
Conjugation
Drug resistance
Effectiveness
Fourier transforms
FTIR
Gold
Methicillin
Microscopy
Nanoparticles
Pathogens
Silver
Staphylococcus aureus
Streptococcus infections
TEM
Transmission electron microscopy
X-ray diffraction
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Summary:Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of -NH 2 and -OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of Streptococcus mutans (S. mutans) and methicillin-resistant Staphylococcus aureus (MRSA) in the range of 61.25-250 µg/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and S. mutans.
ISSN:2169-1401
2169-141X
DOI:10.1080/21691401.2022.2144340