Cerebrolysin in Patients with TBI: Systematic Review and Meta-Analysis

TBI (traumatic brain injury) is one of the most common causes of deaths and failure to return to society according to the latest statistics. Cerebrolysin is a drug approved for use in patients diagnosed with TBI. It is a mixture of neuropeptides derived from purified porcine brain proteins and multi...

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Bibliographic Details
Published in:Brain sciences 2023-03, Vol.13 (3), p.507
Main Authors: Jarosz, Konrad, Kojder, Klaudyna, Andrzejewska, Agata, Solek-Pastuszka, Joanna, Jurczak, Anna
Format: Article
Language:English
Subjects:
Algorithms
Alzheimer's disease
Analysis
Brain
Cerebrolysin
Drug approval
Edema
Homeostasis
Immunology
Injuries
Medical diagnosis
Medical research
Medicine, Experimental
Meta-analysis
Mortality
Neurogenesis
Neuropeptides
Neuroprotection
neuroprotective treatment
Patients
Statistical analysis
Systematic Review
TBI
Trauma
Traumatic brain injury
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Summary:TBI (traumatic brain injury) is one of the most common causes of deaths and failure to return to society according to the latest statistics. Cerebrolysin is a drug approved for use in patients diagnosed with TBI. It is a mixture of neuropeptides derived from purified porcine brain proteins and multiple experimental studies have proven its neuroprotective and neurorestorative properties both in vitro and in vivo. In our meta-analysis, we analyze the latest clinical study reports on the use of Cerebrolysin in patients with TBI. The authors searched the databases: Pub Med, Cinahl, Web Of Science, and Embase from database inception until 11th July 2022. Ten clinical studies were eligible and included in the final analysis, including both retrospective and prospective studies of 8749 patients. Treatment with Cerebrolysin was associated with a statistically significant change in GCS and GOS. Mortality of any cause and the length of stay was not affected by the treatment. Our findings support and confirm the beneficial effects of Cerebrolysin treatment on the clinical outcome of patients after TBI. Further multi-center studies to optimize dosing and time of administration should be conducted.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13030507