Comparative Analysis of Methicillin-Resistant Staphylococcus pseudintermedius Prevalence and Resistance Patterns in Canine and Feline Clinical Samples: Insights from a Three-Year Study in Germany

The emergence of methicillin-resistant (MRSP) presents a significant public health concern globally, particularly within veterinary medicine. MRSP's resistance to multiple antibiotics is limiting treatment options and potentially leading to severe infections in companion animals. This study aim...

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Bibliographic Details
Published in:Antibiotics (Basel) 2024-07, Vol.13 (7), p.660
Main Authors: Feuer, Leonie, Frenzer, Stefanie Katharina, Merle, Roswitha, Bäumer, Wolfgang, Lübke-Becker, Antina, Klein, Babette, Bartel, Alexander
Format: Article
Language:English
Subjects:
Ampicillin
AMR monitoring
Animals
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Cats
Clindamycin
companion animals
Comparative analysis
Datasets
Diagnostic systems
Dogs
Drug resistance
Health aspects
High resistance
Infection
Infections
Legislation
Methicillin
Microbiology
MRSP
Public health
retrospective
Staphylococcus pseudintermedius
Sulfamethoxazole
Surveillance
Trends
Trimethoprim
Veterinary medicine
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Summary:The emergence of methicillin-resistant (MRSP) presents a significant public health concern globally, particularly within veterinary medicine. MRSP's resistance to multiple antibiotics is limiting treatment options and potentially leading to severe infections in companion animals. This study aimed to understand antimicrobial resistance in dogs and cats, focusing on MRSP resistance patterns and its prevalence in Germany. We analyzed results of bacterial diagnostic samples from canines and felines, sourced from a German veterinary diagnostic microbiology laboratory between 2019 and 2021. This dataset included samples from 3491 veterinary practices, covering 33.1% of veterinary practices and clinics in Germany. MRSP rates were detailed by host species, sample types and co-resistance patterns. Analysis of 175,171 bacterial examination results revealed in 44,880 samples, yielding a 25.6% isolation rate. was more prevalent in dogs (35.0%) than cats (3.6%). Methicillin resistance was found in 7.5% of all isolates. MRSP prevalence was higher in feline samples (16.1%, 95% CI 14.4-17.8) compared to canine samples (7.1%, 95% CI 6.8-7.0). showed high resistance rates to ampicillin (cats: 48.6%, dogs: 67.6%) and clindamycin (cats: 37.2%, dogs: 32.7%), while MRSP exhibited high co-resistance to clindamycin (cats: 82.8%, dogs: 85.4%) and sulfamethoxazole + trimethoprim (cats: 66.4%, dogs: 66.2%). Our study revealed distinct resistance patterns of MRSP in cats compared to dogs, highlighting the need for tailored treatment approaches and the importance of antimicrobial resistance surveillance.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13070660