The role of fish oil in attenuating cardiac oxidative stress, inflammation and fibrosis in rat model of thyrotoxicosis

Hyperthyroidism is associated with cardiovascular complications. Fish oil reduces risk of cardiovascular diseases. This study aims to evaluate the impact of fish oil on myocardial oxidative stress, inflammation and fibrosis in rat model of thyrotoxicosis. Rats were randomized into four groups; contr...

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Bibliographic Details
Published in:Heliyon 2019-12, Vol.5 (12), p.e02976-e02976, Article e02976
Main Authors: Mayyas, F., Alsaheb, A., Alzoubi, K.H.
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular disease
Endocrinology
Fibrosis
Fish oil
Health sciences
Hyperthyroidism
Inflammation
Microbiology
Molecular biology
Omega 3
Oxidative stress
Pathology
Pathophysiology
Pharmaceutical science
Pharmacology
Thyrotoxicosis
Toxicology
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Summary:Hyperthyroidism is associated with cardiovascular complications. Fish oil reduces risk of cardiovascular diseases. This study aims to evaluate the impact of fish oil on myocardial oxidative stress, inflammation and fibrosis in rat model of thyrotoxicosis. Rats were randomized into four groups; control rats, fish oil treated rats (FO, 100mg omega-3/100g body weight/day), hyperthyroid rats (Hyper, i.p levothyroxine 3 mg/kg/day), and hyperthyroid rats treated with fish oil (Hyper + FO) for 8 weeks. Changes in oxidants/antioxidants, inflammatory and fibrotic markers were measured. Thyrotoxicosis increased serum endothelin-1, thiobarbituric acid reactive substances (TBARS) and reduced activities of cardiac catalase and super oxide dismutase (SOD). Cardiac fibrosis paralleled with a decrease of matrix metalloproteinase -2 (MMP2) levels were observed in Hyper group. Use of FO increased activities of SOD and catalase, increased TBARS levels, and attenuated cardiac fibrosis by normalizing MMP-2 levels. Use of FO may attenuate cardiac oxidative stress and fibrosis in hyperthyroid states. Fish oil; Omega 3; Cardiovascular disease; Hyperthyroidism; Thyrotoxicosis; Oxidative stress; Fibrosis; Inflammation; Microbiology; Pharmaceutical science; Molecular biology; Pathophysiology; Health sciences; Cardiology; Pathology; Pharmacology; Toxicology; Endocrinology
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2019.e02976