Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018

Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not express...

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Bibliographic Details
Published in:Emerging infectious diseases 2022-05, Vol.28 (5), p.967-976
Main Authors: Mir-Cros, Alba, Moreno-Mingorance, Albert, Martín-Gómez, M Teresa, Abad, Raquel, Bloise, Iván, Campins, Magda, González-Praetorius, Alejandro, Gutiérrez, M Nieves, Martín-González, Héctor, Muñoz-Almagro, Carmen, Orellana, M Ángeles, de Pablos, Manuela, Roca-Grande, Josep, Rodrigo, Carlos, Rodríguez, M Elena, Uriona, Sonia, Vidal, M José, Pumarola, Tomàs, Larrosa, M Nieves, González-López, Juan José
Format: Article
Language:English
Subjects:
Antigens
bacteria
Bacterial Outer Membrane Proteins - genetics
Bordetella pertussis
Control
Distribution
Epidemics
Genetic aspects
Genomes
Humans
Identification and classification
Inactivation
Membrane proteins
Mutation
Pertactin-Deficient
Pertussis Vaccine
phylogenetic evolution
Phylogenetics
Phylogeny
Population
Risk factors
Spain - epidemiology
Statistics
Vaccines
virulence factors
Virulence Factors, Bordetella - genetics
Whooping cough
Whooping Cough - epidemiology
Whooping Cough - prevention & control
with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018
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Summary:Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(-292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2805.211958