Microscopic alterations in Fasciola hepatica from sheep treated with albendazole

Currently, albendazole is one of the most commonly used drugs because of its affordability. The objective was to evaluate the histopathology of Fasciola hepatica specimens. For this, the efficacy test was performed on sheep treated with albendazole at the dose recommended for F. hepatica, in which t...

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Bibliographic Details
Published in:Revista brasileira de parasitologia veterinaria 2019-01, Vol.28 (1), p.33-39
Main Authors: Carneiro, Milena Batista, Avelar, Barbara Rauta, Archanjo, Anderson Barros, Martins, Isabella Vilhena Freire, Nunes, Louisiane de Carvalho, Scott, Fabio Barbour
Format: Article
Language:English
Subjects:
albendazol
Albendazole - administration & dosage
Animals
Anthelmintics - administration & dosage
Fasciola hepatica - drug effects
Fascioliasis - drug therapy
Fascioliasis - parasitology
Fascioliasis - veterinary
Fasciolose
Feces - parasitology
Female
histopatologia
Male
Parasite Egg Count
PARASITOLOGY
Sheep - parasitology
Sheep Diseases - drug therapy
Sheep Diseases - parasitology
tratamento
VETERINARY SCIENCES
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Summary:Currently, albendazole is one of the most commonly used drugs because of its affordability. The objective was to evaluate the histopathology of Fasciola hepatica specimens. For this, the efficacy test was performed on sheep treated with albendazole at the dose recommended for F. hepatica, in which the helminths recovered at necropsy were counted and separated for histology. Spermatogenic cells from parasites recovered from treated and control sheep were examined by microscopy. The fecal egg-count reduction test revealed 97.06% efficacy of albendazole in the treatment of F. hepatica. Changes in testicular tubule cells started 48 hours after treatment and became evident within 72 hours, at which point it became difficult to identify cell types. Primary and secondary spermatogonia became increasingly rare and intercellular vacuolization was more evident. Signs of apoptosis, with pycnotic nuclei and evidence of keriorrexia were observed at all times. Cell debris was identified 96 hours after treatment. The results indicated that parasitic spermatogenesis was severely affected by albendazole and demonstrated the importance of the use of histopathology for the diagnosis of therapeutic efficacy in field strains.
ISSN:0103-846X
1984-2961
1984-2961
DOI:10.1590/S1984-296120180095