Identification of Potential SARS-CoV-2 CD8 + T Cell Escape Mutants

Memory SARS-CoV-2-specific CD8 T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutatio...

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Bibliographic Details
Published in:Vaccines (Basel) 2022-03, Vol.10 (4), p.542
Main Authors: Ahmed, Syed Faraz, Sohail, Muhammad Saqib, Quadeer, Ahmed Abdul, McKay, Matthew R
Format: Article
Language:English
Subjects:
Brief Report
CD8 antigen
CD8+ T cell epitopes
Coronaviruses
COVID-19
COVID-19 vaccines
Epitopes
Genomes
Histocompatibility antigen HLA
immune escape
Immunological memory
Immunology
immunoprevalent
Infections
Lymphocytes
Lymphocytes T
Memory cells
Mutants
Mutation
mutations
Peptides
Proteins
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
T cell receptors
Vaccination
Viral diseases
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Summary:Memory SARS-CoV-2-specific CD8 T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutations in future SARS-CoV-2 variants that lead to widespread T cell escape. The capacity for SARS-CoV-2 mutations to escape memory T cell responses requires comprehensive experimental investigation, though this is prohibited by the large number of SARS-CoV-2 mutations that have been observed. To guide targeted experimental studies, here we provide a screened list of potential SARS-CoV-2 T cell escape mutants. These mutants are identified as candidates for T cell escape as they lie within CD8 T cell epitopes that are commonly targeted in individuals and are predicted to abrogate HLA-peptide binding.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10040542