The Induced Pluripotent Stem Cells in Articular Cartilage Regeneration and Disease Modelling: Are We Ready for Their Clinical Use?

The development of induced pluripotent stem cells has brought unlimited possibilities to the field of regenerative medicine. This could be ideal for treating osteoarthritis and other skeletal diseases, because the current procedures tend to be short-term solutions. The usage of induced pluripotent s...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-02, Vol.11 (3), p.529
Main Authors: Lach, Michał S, Rosochowicz, Monika A, Richter, Magdalena, Jagiełło, Inga, Suchorska, Wiktoria M, Trzeciak, Tomasz
Format: Article
Language:English
Subjects:
Antigens
Arthritis
Biomechanics
Cartilage
Cartilage diseases
Cartilage, Articular
Cell Differentiation
chondrodysplasias
Chondrogenesis
Collagen
disease modelling
Drug screening
Fibroblasts
Gene expression
Humans
Hyaluronic acid
Induced Pluripotent Stem Cells
iPSC
Joint surgery
Older people
Osteoarthritis
Pluripotency
Quality of life
Regenerative Medicine
Review
Stem cells
Transcription factors
Transplants & implants
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Summary:The development of induced pluripotent stem cells has brought unlimited possibilities to the field of regenerative medicine. This could be ideal for treating osteoarthritis and other skeletal diseases, because the current procedures tend to be short-term solutions. The usage of induced pluripotent stem cells in the cell-based regeneration of cartilage damages could replace or improve on the current techniques. The patient's specific non-invasive collection of tissue for reprogramming purposes could also create a platform for drug screening and disease modelling for an overview of distinct skeletal abnormalities. In this review, we seek to summarise the latest achievements in the chondrogenic differentiation of pluripotent stem cells for regenerative purposes and disease modelling.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11030529