Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut

Intestinal barrier immaturity, or "leaky gut", is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. Exacerbated intestinal immune responses, gut microbiota dysbiosis, and heightened barrier injury are considered primary triggers of aberrant intestinal...

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Bibliographic Details
Published in:Frontiers in immunology 2022-02, Vol.13, p.815046
Main Authors: Lemme-Dumit, Jose M, Song, Yang, Lwin, Hnin Wai, Hernandez-Chavez, Claudia, Sundararajan, Sripriya, Viscardi, Rose M, Ravel, Jacques, Pasetti, Marcela F, Ma, Bing
Format: Article
Language:English
Subjects:
Cytokines - genetics
fecal cytokines
Gastrointestinal Microbiome - physiology
gut microbiome
Humans
Immunology
Infant, Newborn
Infant, Premature
intestinal barrier maturation
local immune phenotype
Milk, Human
Phenotype
preterm infants
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Summary:Intestinal barrier immaturity, or "leaky gut", is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. Exacerbated intestinal immune responses, gut microbiota dysbiosis, and heightened barrier injury are considered primary triggers of aberrant intestinal maturation in early life. Inordinate host immunity contributes to this process, but the precise elements remain largely uncharacterized, leaving a significant knowledge gap in the biological underpinnings of gut maturation. In this study, we investigated the fecal cytokine profile and gut microbiota in a cohort of 40 early preterm infants
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.815046