Incorporation of acetate into fatty acids and lecithin by lung slices from fetal and newborn lambs

Incorporation of acetate-1-(14)C into phospholipids and fatty acids by lung slices from fetal and newborn lambs and from ewes was studied in vitro. The distribution of radioactivity in the fatty acids of neutral lipids, phospholipids, and lecithin was determined. Acetate-1-(14)C was incorporated int...

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Bibliographic Details
Published in:Journal of lipid research 1967-07, Vol.8 (4), p.335-341
Main Authors: Chida, N, Adams, F H
Format: Article
Language:English
Subjects:
acetate-1-14C
Acetates - metabolism
Aging
Animals
Animals, Newborn - metabolism
Carbon Isotopes
Chromatography
fatty acids
Fatty Acids - biosynthesis
Fetus - metabolism
In Vitro Techniques
incorporation
lecithin
Lipids - analysis
lung
Lung - metabolism
Phosphatidylcholines - biosynthesis
Phospholipids - analysis
saturated
Sheep
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Summary:Incorporation of acetate-1-(14)C into phospholipids and fatty acids by lung slices from fetal and newborn lambs and from ewes was studied in vitro. The distribution of radioactivity in the fatty acids of neutral lipids, phospholipids, and lecithin was determined. Acetate-1-(14)C was incorporated into myristic, palmitic, and C(18) fatty acids. Of the lecithin fatty acids, myristic and palmitic were the major radioactive fatty acids. The results indicate that the lung of fetal lambs is able to synthesize lecithin containing saturated fatty acids, a major constituent of pulmonary surfactant. A marked increase in the rate of acetate incorporation into lecithin was observed during maturation, and these rates were higher than those obtained in the ewes. A possible relationship between developmental changes in lecithin biosynthesis and pulmonary surfactant is discussed.
ISSN:0022-2275
DOI:10.1016/S0022-2275(20)39563-8