Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection

is an emerging species responsible for infections comparable to those induced by . It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (17), p.6245
Main Authors: Diot, Alan, Dyon-Tafani, Virginie, Bergot, Marine, Tasse, Jason, Martins-Simões, Patricia, Josse, Jérôme, Valour, Florent, Laurent, Frédéric
Format: Article
Language:English
Subjects:
Ablation
Antibiotics
Antimicrobial agents
Bacteria
Bacterial Proteins - genetics
biofilm
Biofilms
Biofilms - growth & development
Biomedical materials
bone and joint infection
Bone growth
Bones
Cell Line
Chronic infection
Cytotoxicity
Female
Gene expression
Genomes
Humans
Immune Evasion
Immune system
intracellular
Joint diseases
Joints (anatomy)
osteoblast
Osteoblasts - cytology
Osteoblasts - microbiology
Pain
Persistent infection
Prostheses
Prosthesis-Related Infections - immunology
Prosthesis-Related Infections - microbiology
Staphylococcal Infections - diagnosis
Staphylococcal Infections - immunology
Staphylococcus - immunology
Staphylococcus - isolation & purification
Staphylococcus - pathogenicity
Staphylococcus argenteus
Staphylococcus infections
Virulence
Virulence Factors - genetics
Whole Genome Sequencing - methods
Young Adult
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Description
Summary:is an emerging species responsible for infections comparable to those induced by . It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in comparison with two other strains of and two isolates. It appeared that this PJI strain combined biofilm formation, osteoblast invasion and intracellular persistence abilities together with genes potentially involved in the escape of the host immune defenses, which might explain the chronicization of the infection.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21176245