Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo

• Published in: BIO web of conferences 2021-01, Vol.37, p.175
• Main Authors: Smirnova, K.Yu, Bannikova, A.V., Kozlov, S.V., Romanova, O.V.
• Format: Article
• Language: English
• ISSN: 2117-4458; 2117-4458
• DOI: 10.1051/bioconf/20213700175

In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wound process in all groups. During the observation period, wound suppuration was not observed; there were 4 cases of a complicated course of the wound process and a fatal outcome in the control group. When conducting studies of local irritant effects, the assessment was carried out in points, in the experimental group it was on average 2 points as for the animals of the control group. The conducted studies allow us to conclude that the drug, when applied to the skin according to the interstate standard GOST ISO 10993-10—2011, has a weak degree of response to irritation in guinea pigs. The application of a permissive dose of the drug to sensitized guinea pigs does not cause a response from the skin, which indicates the absence of allergenic properties in this composition.