Sulfonamide Residues: Honey Quality in the Czech Market

In this study, we determined four sulfonamide compounds (sulfadiazine, sulfadoxine, sulfamethoxazole, and sulfathiazole) in honey marketed in the Czech Republic (Brno). The content of these compounds was monitored in 50 honeys with different botanical and geographical origin. Preanalytical treatment...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food quality 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Dluhosova, Sandra, Borkovcova, Ivana, Kaniova, Lenka, Vorlova, Lenka
Format: Article
Language:English
Subjects:
Annual reports
Antibiotics
Chromatography
Ethylenediaminetetraacetic acid
Food
Food quality
Formic acid
Honey
Hydrolysis
Ionization
Ions
Laboratories
Legislation
Liquid chromatography
Mass spectrometry
Methods
Nitriles
Organic acids
Scientific imaging
Sulfadiazine
Tetracycline
Tetracyclines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we determined four sulfonamide compounds (sulfadiazine, sulfadoxine, sulfamethoxazole, and sulfathiazole) in honey marketed in the Czech Republic (Brno). The content of these compounds was monitored in 50 honeys with different botanical and geographical origin. Preanalytical treatment included acidic hydrolysis with 10% trichloroacetic acid (TCA) and double extraction with acetonitrile and dichloromethane. Chromatographic analysis was performed by ultraperformance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) using a triple quadrupole (QqQ) in positive ionization mode (ESI+). For separation, the mobile phase was a 0.05% aqueous solution of formic acid (A) and 0.05% formic acid in methanol (B) with a gradient elution of 0–3 minutes: 10% B; 3–3.6 min: 90% B; and 3.6–5 min: 10% B, flow rate 0.30 ml/min. Three positive samples (6%) were found containing sulfadiazine (232.88 and 618.87 μg/kg) and sulfamethoxazole (62.64 μg/kg). According to the country of origin, two of these honeys were from European Union (EU) countries, and one was labeled as a blend of honey from EU and non-EU countries.
ISSN:0146-9428
1745-4557
DOI:10.1155/2018/2939207