Synoviocyte detachment: an overlooked yet crucial histological aspect in rheumatoid arthritis

Rheumatoid arthritis (RA) is a prevalent autoimmune disorder that leads to chronic joint inflammation, deformity, disability, and systemic complications. This study aimed to analyze the clinical characteristics and synovial pathology of RA patients with synoviocyte detachment, and explore the factor...

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Published in:BMC musculoskeletal disorders 2024-10, Vol.25 (1), p.829-8, Article 829
Main Authors: Wang, Bihua, Li, Jianbin, Huang, Yiping, Wu, Rui
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - pathology
Biopsy
Blood vessels
Care and treatment
Cell growth
Cell number
Cell proliferation
Development and progression
Ethics
Female
Health aspects
Health risk assessment
Humans
Inflammation
Lymphocytes
Macrophages
Male
Medical records
Methods
Middle Aged
Neovascularization
Normal distribution
Pathology
Patient outcomes
Patients
Proteins
Quality of life
Regression analysis
Retrospective Studies
Rheumatoid arthritis
Rheumatology
Risk factors
Synovial Membrane - pathology
Synovial pathology
Synoviocyte Detachment
Synoviocytes - pathology
Vascularization
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Li, Jianbin
Huang, Yiping
Wu, Rui
description Rheumatoid arthritis (RA) is a prevalent autoimmune disorder that leads to chronic joint inflammation, deformity, disability, and systemic complications. This study aimed to analyze the clinical characteristics and synovial pathology of RA patients with synoviocyte detachment, and explore the factors associated with this phenomenon. This was a retrospective cohort study included RA patients who underwent synovial biopsy at our center from April to September 2023. Demographic, clinical, laboratory, and synovial histological data were retrospectively collected from medical records at the time of joint synovial biopsy in patients. Microscopic examination of hematoxylin and eosin (HE)-stained synovial tissue sections categorized the samples into synoviocyte detachment and no-synoviocyte detachment groups. Clinical characteristics and synovial pathological changes were compared between the two groups, and the factors associated with synoviocyte detachment were explored through logistic regression analysis. Fifty-five RA patients were enrolled; 45 were females, and the mean age was 53.4 ± 11.8 years. Nine RA patients exhibited synoviocyte detachment. A total of 46 RA patients in the no-synoviocyte detachment group (15 with a normal lining layer and 31 with synovial cell proliferation) were included. Compared with the no-synoviocyte detachment group, the synoviocyte detachment group presented higher RF, ESR, CRP and DAS28-CRP levels (P 
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This study aimed to analyze the clinical characteristics and synovial pathology of RA patients with synoviocyte detachment, and explore the factors associated with this phenomenon. This was a retrospective cohort study included RA patients who underwent synovial biopsy at our center from April to September 2023. Demographic, clinical, laboratory, and synovial histological data were retrospectively collected from medical records at the time of joint synovial biopsy in patients. Microscopic examination of hematoxylin and eosin (HE)-stained synovial tissue sections categorized the samples into synoviocyte detachment and no-synoviocyte detachment groups. Clinical characteristics and synovial pathological changes were compared between the two groups, and the factors associated with synoviocyte detachment were explored through logistic regression analysis. Fifty-five RA patients were enrolled; 45 were females, and the mean age was 53.4 ± 11.8 years. Nine RA patients exhibited synoviocyte detachment. A total of 46 RA patients in the no-synoviocyte detachment group (15 with a normal lining layer and 31 with synovial cell proliferation) were included. Compared with the no-synoviocyte detachment group, the synoviocyte detachment group presented higher RF, ESR, CRP and DAS28-CRP levels (P &lt; 0.05). The synoviocyte detachment group exhibited more prominent neovascularization (P &lt; 0.05). ESR, DAS28-CRP and synovial neovascularization were risk factors associated with synoviocyte detachment in RA patients. RA patients with synoviocyte detachment exhibit elevated clinical disease activity, marked by pronounced synovial pathology featuring increased neovascularization and less inflammatory cell infiltration. A significant reduction in lymphocyte count compared with patients with synovial cell proliferation was also observed.</description><identifier>ISSN: 1471-2474</identifier><identifier>EISSN: 1471-2474</identifier><identifier>DOI: 10.1186/s12891-024-07935-8</identifier><identifier>PMID: 39434039</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - pathology ; Biopsy ; Blood vessels ; Care and treatment ; Cell growth ; Cell number ; Cell proliferation ; Development and progression ; Ethics ; Female ; Health aspects ; Health risk assessment ; Humans ; Inflammation ; Lymphocytes ; Macrophages ; Male ; Medical records ; Methods ; Middle Aged ; Neovascularization ; Normal distribution ; Pathology ; Patient outcomes ; Patients ; Proteins ; Quality of life ; Regression analysis ; Retrospective Studies ; Rheumatoid arthritis ; Rheumatology ; Risk factors ; Synovial Membrane - pathology ; Synovial pathology ; Synoviocyte Detachment ; Synoviocytes - pathology ; Vascularization</subject><ispartof>BMC musculoskeletal disorders, 2024-10, Vol.25 (1), p.829-8, Article 829</ispartof><rights>2024. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c445t-e6c599d4f9f6352b8c109c1961e50de3f9b7988dca223b863c5023fb27f11f6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492537/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3126416818?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39434039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bihua</creatorcontrib><creatorcontrib>Li, Jianbin</creatorcontrib><creatorcontrib>Huang, Yiping</creatorcontrib><creatorcontrib>Wu, Rui</creatorcontrib><title>Synoviocyte detachment: an overlooked yet crucial histological aspect in rheumatoid arthritis</title><title>BMC musculoskeletal disorders</title><addtitle>BMC Musculoskelet Disord</addtitle><description>Rheumatoid arthritis (RA) is a prevalent autoimmune disorder that leads to chronic joint inflammation, deformity, disability, and systemic complications. 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Nine RA patients exhibited synoviocyte detachment. A total of 46 RA patients in the no-synoviocyte detachment group (15 with a normal lining layer and 31 with synovial cell proliferation) were included. Compared with the no-synoviocyte detachment group, the synoviocyte detachment group presented higher RF, ESR, CRP and DAS28-CRP levels (P &lt; 0.05). The synoviocyte detachment group exhibited more prominent neovascularization (P &lt; 0.05). ESR, DAS28-CRP and synovial neovascularization were risk factors associated with synoviocyte detachment in RA patients. RA patients with synoviocyte detachment exhibit elevated clinical disease activity, marked by pronounced synovial pathology featuring increased neovascularization and less inflammatory cell infiltration. 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This study aimed to analyze the clinical characteristics and synovial pathology of RA patients with synoviocyte detachment, and explore the factors associated with this phenomenon. This was a retrospective cohort study included RA patients who underwent synovial biopsy at our center from April to September 2023. Demographic, clinical, laboratory, and synovial histological data were retrospectively collected from medical records at the time of joint synovial biopsy in patients. Microscopic examination of hematoxylin and eosin (HE)-stained synovial tissue sections categorized the samples into synoviocyte detachment and no-synoviocyte detachment groups. Clinical characteristics and synovial pathological changes were compared between the two groups, and the factors associated with synoviocyte detachment were explored through logistic regression analysis. Fifty-five RA patients were enrolled; 45 were females, and the mean age was 53.4 ± 11.8 years. Nine RA patients exhibited synoviocyte detachment. A total of 46 RA patients in the no-synoviocyte detachment group (15 with a normal lining layer and 31 with synovial cell proliferation) were included. Compared with the no-synoviocyte detachment group, the synoviocyte detachment group presented higher RF, ESR, CRP and DAS28-CRP levels (P &lt; 0.05). The synoviocyte detachment group exhibited more prominent neovascularization (P &lt; 0.05). ESR, DAS28-CRP and synovial neovascularization were risk factors associated with synoviocyte detachment in RA patients. RA patients with synoviocyte detachment exhibit elevated clinical disease activity, marked by pronounced synovial pathology featuring increased neovascularization and less inflammatory cell infiltration. A significant reduction in lymphocyte count compared with patients with synovial cell proliferation was also observed.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39434039</pmid><doi>10.1186/s12891-024-07935-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source Publicly Available Content (ProQuest); PubMed Central
subjects Adult
Aged
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - pathology
Biopsy
Blood vessels
Care and treatment
Cell growth
Cell number
Cell proliferation
Development and progression
Ethics
Female
Health aspects
Health risk assessment
Humans
Inflammation
Lymphocytes
Macrophages
Male
Medical records
Methods
Middle Aged
Neovascularization
Normal distribution
Pathology
Patient outcomes
Patients
Proteins
Quality of life
Regression analysis
Retrospective Studies
Rheumatoid arthritis
Rheumatology
Risk factors
Synovial Membrane - pathology
Synovial pathology
Synoviocyte Detachment
Synoviocytes - pathology
Vascularization
title Synoviocyte detachment: an overlooked yet crucial histological aspect in rheumatoid arthritis
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