Discriminating performance of macular ganglion cell-inner plexiform layer thicknesses at different stages of glaucoma

To determine the discriminating performance of the macular ganglion cell-inner plexiform layer (GC-IPL) parameters between all the consecutive stages of glaucoma (from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve f...

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Bibliographic Details
Published in:International journal of ophthalmology 2019-03, Vol.12 (3), p.464-471
Main Authors: Ustaoglu, Melih, Solmaz, Nilgun, Onder, Feyza
Format: Article
Language:English
Subjects:
cirrus hd-oct
Clinical Research
ganglion cell-inner plexiform layer
glaucoma suspect
optic nerve head
retinal nerve fiber layer
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Summary:To determine the discriminating performance of the macular ganglion cell-inner plexiform layer (GC-IPL) parameters between all the consecutive stages of glaucoma (from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer (RNFL) parameters and optic nerve head (ONH) parameters. Totally 147 eyes (40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography (OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve (AUC) of the receiver operating characteristics. All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients (
ISSN:2222-3959
2227-4898
DOI:10.18240/ijo.2019.03.18