T-Cell Epitope-Based Vaccines: A Promising Strategy for Prevention of Infectious Diseases

With the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines. T-cell epitope-based vaccines leverage specific immunogenic peptides to elicit prot...

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Bibliographic Details
Published in:Vaccines (Basel) 2024-10, Vol.12 (10), p.1181
Main Authors: Song, Xin, Li, Yongfeng, Wu, Hongxia, Qiu, Huaji, Sun, Yuan
Format: Article
Language:English
Subjects:
Antibodies
Antigenic determinants
Antigens
Artificial intelligence
cell-mediated immune responses
Cells
Communicable diseases
epitope identification
Epitopes
Identification methods
Immune response
Immune system
Immunogenicity
Infectious diseases
Information technology
Ligands
Lymphocytes T
Mass spectrometry
Medical research
Pathogens
Peptides
Research methodology
Risk reduction
Scientific imaging
Side effects
T cells
T-cell epitopes
Vaccines
Viral infections
Viruses
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Description
Summary:With the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines. T-cell epitope-based vaccines leverage specific immunogenic peptides to elicit protective T-cell responses against infectious pathogens. Compared to traditional vaccines, they provide superior efficacy and safety, minimizing the risk of adverse side effects. In this review, we summarized and compared the prediction and identification methods of T-cell epitopes. By integrating bioinformatic prediction and experimental validation, efficient and precise screening of T-cell epitopes can be achieved. Importantly, we delved into the development approaches to diverse T-cell epitope-based vaccines, comparing their merits and demerits, as well as discussing the prevalent challenges and perspectives in their applications. This review offers fresh perspectives for the formulation of safe and efficacious epitope-based vaccines for the devastating diseases against which no vaccines are currently available.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines12101181