Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44

Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive...

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Bibliographic Details
Published in:Marine drugs 2013-08, Vol.11 (8), p.3068-3076
Main Authors: Li, Chun-Shun, Li, Xiao-Ming, Gao, Shu-Shan, Lu, Yan-Hua, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
anthranilic acid
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Colonic Neoplasms - drug therapy
Colonic Neoplasms - pathology
cytotoxicity
Geologic Sediments
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
marine fungus
Mass Spectrometry
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - chemistry
Mycophenolic Acid - isolation & purification
Mycophenolic Acid - pharmacology
ortho-Aminobenzoates - chemistry
ortho-Aminobenzoates - isolation & purification
ortho-Aminobenzoates - pharmacology
Penicillium - chemistry
Penicillium paneum
sediment
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Summary:Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
ISSN:1660-3397
1660-3397
DOI:10.3390/md11083068