A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action of GA on iron-induced neuronal cell damage by employing the PC12 cell line and primary culture of rat cortical neurons (PCRCN). A strong prot...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2011, Vol.116(1), pp.36-46
Main Authors: Figueredo, Yanier Núñez, García-Pupo, Laura, Rubio, Osmany Cuesta, Hernández, René Delgado, Naal, Zeki, Curti, Carlos, Pardo Andreu, Gilberto L.
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants - chemistry
Antioxidants - pharmacology
Ascorbic Acid - chemistry
Ascorbic Acid - toxicity
Benzophenones - chemistry
Benzophenones - pharmacology
Cell Survival - drug effects
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - drug effects
Deoxyribose - metabolism
Embryo, Mammalian
Ferric Compounds - chemistry
Ferric Compounds - toxicity
guttiferone-A
iron
Iron Chelating Agents - chemistry
Iron Chelating Agents - pharmacology
iron chelation
Kinetics
Malondialdehyde - metabolism
Neurons - drug effects
Neurons - metabolism
neuroprotection
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Oxidants - chemistry
Oxidants - toxicity
Oxidation-Reduction - drug effects
Oxidative Stress - drug effects
PC12 Cells
Rats
Rats, Wistar
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Summary:Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action of GA on iron-induced neuronal cell damage by employing the PC12 cell line and primary culture of rat cortical neurons (PCRCN). A strong protection by GA, assessed by the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carbox-anilide (XTT) assay, was revealed, with IC50 values
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.10273FP