Are Mucosa CD4+/CD8+ T-Cells Expressions Correlated with the Endoscopic Appearance of Chronic Gastritis Related with Helicobacter pylori Infection?

Local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of T(h)1 cytokine-producing CD4+ and CD8+T-cells Objective. To investigate the correlation between CD4+/CD8+ T-cells in...

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Bibliographic Details
Published in:Acta medica Iranica 2016-06, Vol.54 (6), p.359-365
Main Authors: Ratnasari, Neneng, Bayupurnama, Putut, Maduseno, Sutanto, Indrarti, Fahmi, Triwikatmani, Catharina, Harijadi, Achmad, Nurdjanah, Siti
Format: Article
Language:English
Subjects:
Adult
CD4 /CD8 T-cells
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Chronic Disease
Chronic gastritis
Cross-Sectional Studies
Female
Gastric lesion
Gastric Mucosa - immunology
Gastric Mucosa - pathology
Gastritis - immunology
Gastritis - metabolism
Gastritis - pathology
Gastroscopy
H. pylori
Helicobacter Infections - immunology
Helicobacter Infections - metabolism
Helicobacter Infections - pathology
Helicobacter pylori - immunology
Humans
Male
Middle Aged
Prospective Studies
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Summary:Local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of T(h)1 cytokine-producing CD4+ and CD8+T-cells Objective. To investigate the correlation between CD4+/CD8+ T-cells in gastric mucosa with endoscopic appearance in chronic gastritis with or without H.pylori infection. Prospective, cross sectional study is performed in a chronic dyspepsia population in July-November 2009 at Dr. Sardjito General Hospital Yogyakarta, Indonesia. The update Sydney system was used to analyze the gastroscopy appearance. Biopsy specimens were stained with HE-stain and IHC-stain. Data were analyzed by t-test, Mann-Whitney and Spearman correlation test. Number of 88 consecutive subjects are enrolled the study (50% male; 50% female), age 46±15 years; 25% H.pylori positive. The expression of CD4+ and CD8+ were higher in H.pylori negative subjects, but only the CD4+ was significant (P=0.011). A significant correlation was found between CD4+ and CD8+ in both subjects (r(Hp+)=0.62 and r(Hp-)=0.68; P
ISSN:0044-6025
1735-9694