Effect of dabai (Canarium odontophyllum) fruit extract on biochemical parameters of induced obese–diabetic rats

• Published in: Journal of functional foods 2014-05, Vol.8, p.139-149
• Main Authors: Mokiran, Nurul Nadirah, Ismail, Amin, Azlan, Azrina, Hamid, Muhajir, Hassan, Fouad Abdulrahman
• Format: Article
• Language: English
• Subjects: Dabai; Glucose; Insulin; Lipid profile; Obese-diabetic; Polyphenol compounds
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2014.03.007

•Effects of dabai extract were investigated in obese-diabetic rats.•The bioactive compounds in dabai fruit were assessed.•Dabai fruit showed an improvement in glucometabolism.•The fruit extract improved HDL-c and LDL-c and possessed hypocholesterolaemic effect.•The fruit extract also reduced the insulin resistance (HOMA-IR). Dabai is one of the most popular indigenous fruits in Sarawak, and is rich in various nutrients. In this study, the effect of dabai fruit extract (300 and 600 mg/kg bw) on the biochemical parameters of obese–diabetic (Ob-db) rats was investigated. After a 4-week treatment period, the dabai extract at a concentration of 600 mg/kg bw (equivalent to 20 g of flesh with skin of fresh fruit) showed a pronounced effect in lowering the plasma glucose level compared with 300 mg extract/kg bw (equivalent to 10 g of flesh with skin of fresh fruit). The dabai extract also significantly reduced the plasma cholesterol and low-density lipoprotein (LDL-c) levels and increased high-density lipoprotein (HDL-c). However, the dabai extract did not increase the insulin level but did increase its sensitivity and reduced insulin resistance (HOMA-IR). This study suggests that dabai extract possesses hypocholesterolaemic properties, has a short-term glucose-lowering effect and improves the lipid profile through synergistic effect of various polyphenols.