Evaluation of Serum Homocysteine and Leptin Levels in Patients with Uveitis

• Published in: Turk oftalmoloji gazetesi 2015-08, Vol.45 (4), p.146-151
• Main Authors: Elbay, Arif Emre, Topalkara, Ayşen, Elbay, Ahmet, Erdoğan, Haydar, Vural, Ayşe, Bahadır Çetin, Abdi
• Format: Article
• Language: English
• Subjects: Behçet’s; homocysteine; leptin; Original; Uveitis
• ISSN: 2149-8695; 1300-0659; 2147-2661; 2149-8709
• DOI: 10.4274/tjo.26539

To evaluate the serum homocysteine (Hcy) and leptin levels in patients with uveitis. The 70 cases included in the study comprised 3 groups: patients with Behçet's uveitis (BU), patients with non-Behçet's uveitis (NBU) and healthy controls. Body mass index was calculated for each subject. Serum Hcy and leptin levels were measured. Furthermore, acute-phase reactants including erythrocyte sedimentation rate (ESR), C-reactive protein and neutrophil count were measured. Serum Hcy levels were 15.04±4.59 µmol/L in the BU group, 15.4±6.87 µmol/L in the NBU group and 13.64±4.72 µmol/L in the control group (p>0.05). The serum leptin levels of male patients in the BU group, NBU group and control group were 4.76±3.54 ng/ml, 6.33±3.74 ng/ml and 5.47±6.33 ng/ml, respectively (p>0.05). When we compared serum leptin levels in female patients and controls, the mean serum leptin concentrations were significantly higher in female BU and NBU patients (24.83±17.62 ng/ml and 28.46±13.90 ng/ml, respectively) than in healthy control volunteers (9.62±6.36 ng/ml, p