Infectivity of human coronavirus in the brain

A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurologica...

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Bibliographic Details
Published in:EBioMedicine 2020-06, Vol.56, p.102799-102799, Article 102799
Main Authors: Cheng, Qi, Yang, Yue, Gao, Jianqun
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2
Animals
Betacoronavirus - isolation & purification
Betacoronavirus - physiology
Brain
Brain - virology
Central Nervous System - metabolism
Central Nervous System - virology
Coronavirus
Coronavirus Infections - pathology
Coronavirus Infections - virology
COVID-19
Dipeptidyl Peptidase 4 - chemistry
Dipeptidyl Peptidase 4 - metabolism
Human
Humans
Middle East Respiratory Syndrome Coronavirus - isolation & purification
Middle East Respiratory Syndrome Coronavirus - physiology
Neuroinvasion
Neurological manifestation
Pandemics
Peptidyl-Dipeptidase A - chemistry
Peptidyl-Dipeptidase A - metabolism
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
Review
SARS-CoV-2
Viral Proteins - chemistry
Viral Proteins - metabolism
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Description
Summary:A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confirmed cases, raising concerns of its potential for intracranial invasion and neurological manifestations, both in the acute phase and in the long-term. At present, it remains unclear the extent to which SARS-CoV-2 is present in the brain, and if so, its pathogenic role in the central nervous system (CNS). Evidence for neuroinvasion and neurovirulence of hCoVs has been recognised in animal and human studies. Given that SARS-CoV-2 belongs to the same family and shares characteristics in terms of receptor binding properties, it is worthwhile exploring its potential CNS manifestations. This review summarises previous findings from hCoVs in relation to the CNS, and compares these with the new strain, aiming to provide a better understanding of the effects of SARS-CoV-2 on the CNS.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2020.102799